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Current Cancer Clinical Trials at DeKalb Medical

DeKalb Medical is currently participating in the following cancer clinical trials. If you see an open trial below that you're interested in, please contact the DeKalb Medical Clinical Trials staff at 404.501.5701 or email us at clinicaltrials@dekalbmedical.org.


AbbVie M12-914:

A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Cancer

Study Abstract: http://clinicaltrials.gov/ct2/show/NCT02163694?term=NCT02163694&rank=1

Eligibility Criteria: Click here for Eligibility Criteria.

Schema: Click here for Schema.


The use of Fulvestrant and/or Anastrozole in Treating Postmenopausal Patients With Stage II-III Breast Cancer Undergoing Surgery

Study Abstract: http://www.cancer.gov/clinicaltrials/search/view?version=healthprofessional&cdrid=753769

Eligibility Criteria: https://www.ctsu.org/readfile.aspx?sectionTypeCode=EC§ionID=33654

Schema: https://www.ctsu.org/readfile.aspx?sectionTypeCode=SCHEMA§ionId=33656

Physician Fact Sheet: https://www.ctsu.org/readfile.aspx?sectionTypeCode=PFS§ionId=33658


A trial for breast patients with Her-2-positive DCIS. This is a trial looking at whether there is better disease free survival in patients who receive 2 doses of Herceptin along with their radiation therapy for DCIS.

Study Abstract: https://clinicaltrials.gov/ct2/show/NCT00769379?term=NSABP+B-43&rank=1

Eligibility Criteria:https://www.ctsu.org/readfile.aspx?sectionid=32&fname=protocols/nsabp/nsabp-b-43/B43_Eligibility_Checklist.pdf

Schema: https://www.ctsu.org/readfile.aspx?sectionid=22&fname=protocols/nsabp/nsabp-b-43/B-43_Schema.pdf

Physician Fact Sheet: https://www.ctsu.org/readfile.aspx?sectionid=31&fname=protocols/nsabp/nsabp-b-43/NSABP_B43_PFS_010612.pdf


A trial for women who have a low percentage of Her-2 overexpression in their breast cancer. This trial is seeking to discover whether these women will benefit from the addition of Herceptin to their course of therapy.

Study Abstract: https://clinicaltrials.gov/ct2/show/NCT01275677

Eligibility Criteria:https://www.ctsu.org/readfile.aspx?sectionid=32&fname=protocols/nsabp/nsabp-b-47/B47_EligibilityChecklist_121311.pdf

Schema: https://www.ctsu.org/readfile.aspx?sectionid=22&fname=protocols/nsabp/nsabp-b-47/B47_Schema_121311.pdf

Physician Fact Sheet: https://www.ctsu.org/readfile.aspx?sectionid=31&fname=protocols/nsabp/nsabp-b-47/NSABP_B47_PFS_121311.pdf


A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy.

Eligibility Criteria:https://www.ctsu.org/readfile.aspx?sectionid=32&fname=protocols/nsabp/nsabp-b-51/B51_EligibilityCriteria_011113.pdf

Schema: https://www.ctsu.org/readfile.aspx?sectionid=22&fname=protocols/nsabp/nsabp-b-51/B51_Schema_011113.pdf


A Randomized Phase III Trial Evaluating Pathologic Complete Response Rates in Patients with Hormone Receptor-Positive, HER2-Positive, Large Operable and Locally Advanced Breast Cancer Treated with Neoadjuvant Therapy of Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab (TCHP) With or Without Estrogen Deprivation.

Study Abstract: https://clinicaltrials.gov/ct2/show/NCT02003209

Eligibility Criteria:https://www.ctsu.org/readfile.aspx?sectionTypeCode=EC§ionID=135012

Schema: https://www.ctsu.org/readfile.aspx?sectionTypeCode=SCHEMA§ionId=135014

S0812:  Temporarily closed to accrual

This is a breast cancer prevention study that evaluates the effects of high dose vitamin D in pre-menopausal women who are at high risk for developing breast cancer.


This is a clinical study for breast cancer patients who have 1-3 positive lymph nodes and a low risk of cancer recurrence. This trial is seeking to better understand if patients benefit from receiving chemotherapy in conjunction with standard endocrine therapy.

SWOG S1207:

Hormone Therapy With or Without Everolimus in Treating Patients With Breast Cancer

Study Abstract: https://clinicaltrials.gov/ct2/show/NCT01674140

Eligibility Criteria:https://www.ctsu.org/readfile.aspx?sectionid=33394

Schema: https://www.ctsu.org/readfile.aspx?sectionTypeCode=SCHEMA§ionId=30775


GOG 0258:

Carboplatin and Paclitaxel With or Without Cisplatin and Radiation Therapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IVA Endometrial Cancer

Study Abstract: https://clinicaltrials.gov/ct2/show/NCT00942357

Eligibility Criteria: Click here for Eligibility Criteria.

Schema: https://www.ctsu.org/readfile.aspx?sectionTypeCode=SCHEMA§ionId=16739

Physician Fact Sheet: https://www.ctsu.org/readfile.aspx?sectionTypeCode=PFS§ionId=19380

GOG 0275:

Erlotinib Hydrochloride or Crizotinib and Chemoradiation Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer

Study Abstract: https://clinicaltrials.gov/ct2/show/NCT01822496

Eligibility Criteria: https://www.ctsu.org/readfile.aspx?sectionid=29532

Schema: https://www.ctsu.org/readfile.aspx?sectionTypeCode=SCHEMA§ionId=29531

Physician Fact Sheet: https://www.ctsu.org/readfile.aspx?sectionTypeCode=PFS§ionId=29533

GOG 0277:

A Phase III Randomized Trial of Gemcitabine (NSC# 613327) Plus Docetaxel (NSC# 628503) Followed by Doxorubicin (NSC# 123127) v. Observation for Uterus-Limited, High Grade Uterine  Leiomyosarcoma

Study Abstract: https://clinicaltrials.gov/ct2/show/NCT01533207

Eligibility Criteria: Click here for Eligibility Criteria.

Schema: https://www.ctsu.org/readfile.aspx?sectionTypeCode=SCHEMA§ionId=29337

Physician Fact Sheet: https://www.ctsu.org/readfile.aspx?sectionTypeCode=PFS§ionId=29339

GOG 0286B:

Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer

Study Abstract: https://clinicaltrials.gov/ct2/show/NCT00946712

Eligibility Criteria: Click here for Eligibility Criteria.

Schema: Click here for Schema.


City of Hope Genetic Registry:

Patients and their families will be given the unique opportunity to take part in a confidential registry and biologic repository to help define the underlying predisposition to cancer. The study will help to answer questions about whether cancers may have a genetic or environmental cause (or both) and ultimately to learn more about susceptibility to cancer.



ECOG E5508:

Randomized Phase III Study of Maintenance Therapy with Bevacizumab, Pemetrexed or Both Following Carboplatin, Paclitaxel and Bevacizumab for Advanced Stage Non-Squamous Non-Small Cell Lung Cancer.

Abstract: https://clinicaltrials.gov/ct2/show/NCT01107626

Schema: https://www.ctsu.org/readfile.aspx?sectionid=22&fname=protocols/ecog/e5508/E5508_Schema_081210.pdf

Physician Fact Sheet: https://www.ctsu.org/readfile.aspx?sectionid=31&fname=protocols/ecog/e5508/E5508_PFS_042712.pdf

RTOG 1306:

Erlotinib Hydrochloride or Crizotinib and Chemoradiation Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer

Study Abstract: http://www.cancer.gov/clinicaltrials/search/view?cdrid=748540&version=HealthProfessional#SitesAndContacts_CDR0000748540

Eligibility Criteria: Click here for Eligibility Criteria.

Schema: https://www.ctsu.org/readfile.aspx?sectionTypeCode=SCHEMA§ionId=33165

SWOG S0819:

A Randomized, Phase III Study Comparing Carboplatin/Paclitaxel or Carboplatin/Paclitaxel/Bevacizumab with or without Concurrent Cetuximab in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC).

Abstract: https://clinicaltrials.gov/ct2/show/NCT00946712

Eligibility Criteria: https://www.ctsu.org/readfile.aspx?sectionid=32&fname=protocols/swog/s0819/S0819_EligibilityCriteria_041512.pdf

Physician Fact Sheet: https://www.ctsu.org/readfile.aspx?sectionid=22&fname=protocols/swog/s0819/S0819_Schema_071509.pdf



PROMIS and NBRST Tumor Registry Study:

These studies incorporate MammaPrint, a 70-gene array, of the participants’ breast tumor. Results are made available to the patient and her physician for discussion of further treatment options. The study is looking at whether the MammaPrint results will have a bearing on treatment options.

PROMIS: https://clinicaltrials.gov/ct2/show/NCT01617954

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